We develop quantitative proteomics technologies to study several key protein complexes involved in DNA replication and chromosome segregation, regarding their composition, dynamics, stability and regulation. Insights from the proteomics analysis are further pursued to study how cells maintain their genome integrity.

Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

The Lab of Dr. Joseph Califano under the sponsorship of the Japan Society for the Promotion of Science (JSPS) will conduct collaborative research on a new strategy for the treatment for HPV-associated oropharyngeal cancer based on comprehensive epigenetic analysis.  This year, we are proud to congratulate Postdoctoral Researcher, Dr. Takuya Nakagawa for his work entitled “Genetic and epigenetic analysis of HPV-positive and HPV-negative Oropharyngeal Squamous Cell Carcinoma”. Dr. Nakagawa graduated from Chiba University School of Medicine in Japan where he also received the Medical Pharmacy Director’s Award.