The McVicker laboratory aims to understand how chromatin state and organization are encoded by the human genome. Our approach to this problem is to exploit naturally occurring human genetic variation to identify sequence variants that disrupt chromatin function. We are currently focused on chromatin within immune cells and we are also interested in how variants that affect chromatin and gene regulation lead to disease risk. The problems that we work on often require the development of sophisticated computational and statistical methods that can extract subtle signals from noisy experimental data.
Bioinformatics and Systems Biology
BISB Research Area(s)
Brief Research Description
Human genetic variation, chromatin and gene regulation in immune cells