Dorothy Sears

Faculty Status
Associate Professor
(858) 534-8898
Bioinformatics and Systems Biology
Brief Research Description
Mechanisms and biomarkers of nsulin resistance, type 2 diabetes, obesity, breast cancer, PPARgamma, inflammation
Lab Description

The focus of my research is on the fields of insulin resistance and obesity in humans, rodents and cell culture models. A new aspect of this research is the study of how insulin resistance promotes breast cancer. We employ systems biology approaches for complex data analysis. Research efforts include the generation of large transcriptomic, metabolomic, proteomic and lipidomic data sets and the analysis of these data sets independently and as network overlays using bioinformatic pathway tools. Our goals are to identify and characterize individual genes and biochemical pathways that regulate insulin resistance and pharmacological insulin sensitization.