Dorothy Sears

Faculty Status
Active
Title
Associate Professor
Email
dsears@ucsd.edu
Phone
(858) 534-8898
Track(s)
Bioinformatics and Systems Biology
Department
Brief Research Description
Mechanisms and biomarkers of nsulin resistance, type 2 diabetes, obesity, breast cancer, PPARgamma, inflammation
Lab Description

The focus of my research is on the fields of insulin resistance and obesity in humans, rodents and cell culture models. A new aspect of this research is the study of how insulin resistance promotes breast cancer. We employ systems biology approaches for complex data analysis. Research efforts include the generation of large transcriptomic, metabolomic, proteomic and lipidomic data sets and the analysis of these data sets independently and as network overlays using bioinformatic pathway tools. Our goals are to identify and characterize individual genes and biochemical pathways that regulate insulin resistance and pharmacological insulin sensitization.