Investigating the impact of Cul3 mutations in brain organoids

Cul3 (Cullin 3) ubiquitin ligase is one of the genes implicated in Autism Spectrum Disorders. We generated brain organoids with Cul3 haploinsufficiency, and collected 10x multiome data on these organoids. The goal of the rotation project is to analyze these data to identify cell types, genes and chromatin states impacted by this ASD mutation. The student is required to have familiarity with single cell RNA data analyses.