Animating spatial transcriptomics

Current approaches profiling the transcriptome of cells in tissues offer a rich yet immobile snapshot of biology. In collaboration with the Kosuri Lab at the Salk Institute, we are developing approaches to infer cell kinematics and tissue infiltration timelines to obtain a finer temporal view of key processes that impact T cell differentiation and function during an anti-tumoral response. This project will rely on the development of both computational tools and wet lab protocols.