Dr. Glass’ primary interests are to understand transcriptional mechanisms that regulate the development and function of macrophages. Macrophages play key roles in immunity, wound repair, development and tissue homeostasis. Dysregulation of macrophage functions contribute to a broad spectrum of human diseases, including atherosclerosis, diabetes, neurodegenerative diseases, and cancer. A major effort of the Glass laboratory is to use genomics assays and associated bioinformatics approaches to understand how macrophage gene expression programs are established and how they are influenced by different tissue environments and disease. An important concept to emerge from these studies is that enhancers can be exploited to deduce the transcription factors and upstream signaling pathways that drive context-specific transcriptional outputs. Students are welcome to select projects from current areas of active investigation.
Bioinformatics and Systems Biology
Brief Research Description
Enhancer Selection and Functions, Macrophage Subtypes, Genetic Variation, Enhancer Transcription