Welcome to the Frazer Lab! We are using two complementary approaches to achieve our goal of identifying and characterizing functional human genetic variants. Our first approach utilizes iPSCORE, a resource that was generated to enable both familial and association-based genetic studies of molecular and physiological phenotypes in induced pluripotent stem cells (iPSCs) and derived cell types. Our second approach involves conducting association studies in well-characterized cohorts with the goal of identifying variants that play roles in human disease and to assess their contributions to disease pathogenesis, progression, and prognosis.
Bioinformatics and Systems Biology
Brief Research Description
Functional Genomics, Omics integration, High-throughput Sequencing, Induced pluripotent stem cells