See Also BISB 201516
See here for a list of projected course offerings for 201516.
Core Requirements for the Bioinformatics and Systems Biology Track
Each student in the Bioinformatics and Systems Biology Track must take the four courses below.

Bioinformatics II (BENG 202/CSE 282). Introduction to Bioinformatics Algorithms (4 units)
(Formerly BENG 202/CSE 257A.) Introduction to methods for sequence analysis. Applications to genome and proteome sequences. Protein structure, sequencestructure analysis.
Prerequisite: Pharm. 201 or consent of instructor. (W) 
Bioinformatics III (BENG 203/CSE 283). Genomics, Proteomics, and Network Biology (4 units)
Annotating genomes, characterizing functional genes, profiling, reconstructing pathways.
Prerequisites: Pharm 201, BENG 202/CSE 282, or consent of instructor. (S) 
Bioinformatics IV (MATH 283). Statistical Methods in Bioinformatics (4 units)
This course will cover material related to the analysis of modern genomic data; sequence analysis, gene expression/functional genomics analysis, and gene mapping/applied population genetics. The course will focus on statistical modeling and inference issues and not on database mining techniques.
Prerequisites: one year of calculus, one statistics course or consent of instructor. 
BNFO 285. Statistical Learning in Bioinformatics (4 units)
A hallmark of bioinformatics is the computational analysis of complex data. The combination of statistics and algorithms produce statistical learning methods that automate the analysis of complex data. Such machine learning methods are widely used in systems biology and bioinformatics. This course provides an introduction to statistical learning and assumes familiarity with key statistical methods. Letter grades only.
Prerequisites: Math 283.
All required Core and Elective courses for the degree must be taken for a letter grade. Students must obtain a “B” or better in courses taken for the degree. If you receive a “B” or lower in a Core or Elective class, or you take it on S/U grading, it does not fulfill your requirements. Please see the Grades FAQ if you have any grades of “B” or lower or “U”.
Seminars
All students in years 12 must take the Colloquium for their track in fall, winter, and spring quarters.

BNFO 281. Seminar in Bioinformatics and Systems Biology (1 unit)
Weekly seminars by faculty and visiting bioinformaticists presenting their research. S/U grades only. May be taken for credit nine times.
All students in years 12 must take the Student Research Talks in fall, winter, and spring quarters.

BNFO 283. Bioinformatics Student Research Talks (1 unit)
Weekly presentations by Bioinformatics and Systems Biology students about Research Projects that are proposed or completed. Faculty mentors are present to contribute critiques and suggestions.
Prerequisites: Bioinformatics and Systems Biology Graduate Students only. (S/U grades only.)
All students must take one of the two ethics courses, SOMI 226 or BIOM 219, by the end of the second year. However, funding sources may require that it be taken the first year, so we recommend taking it the first year.
Special registration procedure: Students must register for the ethics course both via TritonLink as well as via the registration form on ethics.ucsd.edu. The course is taken by many UCSD employees (not just students), so the Ethics Program uses its own registration form. Registration on TritonLink is necessary for students to receive course credit.

SOMI 226. Scientific Ethics (1 unit)
See BIOM 219 description.

BIOM 219. Ethics in Scientific Research (1 unit)
Overview of ethical issues in scientific research, conflicts of interest; national, statewide and campus issues and requirement; ethical issues in publications; authorship; retention of research records; tracing of research records; attribution; plagiarism; copyright considerations; primary, archival and meeting summary publications; ethical procedures and policies; NIH, NSF, California and UC San Diego; case studies and precedents in ethics.
Prerequisites: consent of instructor.
Research and Teaching Requirements
During the academic year, all students must be enrolled in the appropriate research course for their level. Students typically do three rotations in year 1 (BNFO 298) and then do research units (BNFO 299) with their thesis advisor in years 2 and later. BNFO 299 units may be varied to meet the fulltime enrollment requirement of 12 units per quarter in fall, winter, and spring. During the summer, students are expected to do research as well, but should not enroll in BNFO 298 or BNFO 299. During all quarters and the summer, students are responsible for satisfying program requirements including proposals, reports, presentations, committee meetings, notifying the graduate coordinator when joining/changing labs, etc.; the only difference is that students do not enroll in BNFO 298 or BNFO 299 in the summer. In addition, each student will make periodic research presentations to the graduate program students/faculty. Students will also discuss their progress at the annual program meeting to be held each year.

BNFO 298. Research Rotation (4–8 units)
Laboratory research of special topics under the direction of a program faculty member. The purpose is to train students in specific research methodologies and identify a laboratory in which to pursue doctoral dissertation research. Three quarters are required for PhD candidates. May be taken for credit six times.
Prerequisites: bioinformatics graduate students and consent of instructor and program. 
BNFO 299. Graduate Research (1–12 units)
Independent work by graduate students engaged in research and writing theses. S/U grades only. May be taken for credit fifteen times.
Prerequisites: bioinformatics and systems biology graduate students and consent of instructor.
All students must serve as a teaching assistant (TA) for at least two quarters. Students should enroll in BNFO 500 (Teaching Experience) or an equivalent course code in another department, during each quarter in which they are a teaching assistant. A typical teaching assistantship is 110 hours/quarter (25% load, 2 units of BNFO 500); however, this varies by class. 220 hours/quarter is a 50% load, 4 units.

BNFO 500. Teaching Assistantship (2–4 units)
Teaching experience in an appropriate Bioinformatics undergraduate or graduate course under direction of the faculty member in charge of the course. Each Ph.D. candidate must complete two academic quarters of experience for S/U grade only. May be taken for credit four times. (F,W,S)
Note: The department in which the teaching assistantship is held may require use of their corresponding course number instead of BNFO 500, e.g., BENG 501, BGGN 500, CHEM 500, CSE 500, MATH 500, etc.
Prerequisites: Graduate standing and consent of instructor (department stamp). (S/U grades only.)
Program Electives
Each student in the Bioinformatics and Systems Biology track will select 16 units of Elective Courses from four distinct Elective Fields (BIO, CS, SB, BMI) delineated below, with at least 4 units from the CS series and 4 units from the BIO series. For example, a student interested in Systems Biology could take one 4 unit class from the CS series, one from the BIO series, one from SB1, and one from SB2.
It is the general policy of the program to be as adaptable as possible to the needs of the individual student. The curriculum committee is receptive to students petitioning to satisfy an Elective requirement by taking a course not listed among the Electives.
Elective BIO1: Biochemistry

BENG 230A. Biochemistry (4 units)
A graduate course in biochemistry especially tailored to the requirements and background of bioengineering graduate students. It will cover the important macro and small molecules in cells that are the major constituents, or that function as signaling molecules or molecular machineries. The structures, pathways, interactions, methodologies, and molecular designs using recombinant DNA technology will be covered.
Prerequisites: restricted to bioengineering graduate students with major code BE75. (F) 
CHEM 209. Macromolecular Recognition (4 units)
Structures and functions of nucleic acids, folding and catalysis of nucleic acids, motifs and domains of proteins, principles of proteinprotein interactions, chemistry of protein/DNA and protein/RNA interfaces, conformational changes in macromolecular recognition.
Prerequisites: biochemistry background and graduate standing, or approval of instructor. 
CHEM 213. Physical Chemistry of Biological Macromolecules (4 units)
(Conjoined with Chem 113.) A discussion of the physical principles governing biological macromolecular structure and function, and the physicochemical experiments used to probe their structure and function. Chem 213 students will be required to complete an additional paper and/or exam beyond that expected of students in Chem 113.
Prerequisites: Chem 140C or 140CH; and Chem 127 or 131 (113); or graduate standing (213). 
CHEM 216. Chemical Biology (4 units)
A discussion of current topics in chemical biology including mechanistic aspects of enzymes and cofactors, use of modified enzymes to alter biochemical pathways, chemical intervention in cellular processes, and natural product discovery.
Prerequisites: graduate standing or consent of instructor. (May not be offered every year.)
Elective BIO2: Molecular Genetics

BICD 100. Genetics (4 units)
An introduction to the principles of heredity emphasizing diploid organisms. Topics include Mendelian inheritance and deviations from classical Mendelian ratios, pedigree analysis, gene interactions, gene mutation, linkage and gene mapping, reverse genetics, population genetics, and quantitative genetics.
Prerequisites: BILD 1. 
BGGN 220. Graduate Molecular Biology (6 units)
Provides a broad, advancedlevel coverage of modern molecular biology for firstyear graduate students. Topics include prokaryotic and eukaryotic gene structure and regulation, chromatin structure, DNA replication, translation, mechanisms of transcription, and an introduction to viruses. OPEN ONLY TO STUDENTS ENROLLED IN A GRADUATE DEGREE PROGRAM. (Letter grades only.) (F)

BGGN 223. Graduate Genetics (6 units)
Provides a broad and extensive advancedlevel coverage of molecular and formal aspects of genetics for firstyear graduate students. Topics covered include: bacterial genetics, recombination in prokaryotes and eukaryotes, mammalian somaticcell genetics, developmental genetics, sex determination, dosage compensation, and immunogenetics. Extensive coverage of the use of model systems like Drosophila and C. elegans is included. General and specific aspects of cellular signaling mechanisms will be covered.
Prerequisites: BGGN 220, 221 and 222. OPEN ONLY TO STUDENTS ENROLLED IN A GRADUATE DEGREE PROGRAM. (Letter grades only.) (S)
Elective BIO3: Cell Biology

BICD 110. Cell Biology (4 units)
The structure and function of cells and cell organelles, cell growth and division, motility, cell differentiation and specialization.
Prerequisites: BIBC 100 or BIBC 102. 
BICD 130. Embryos, Genes, and Development (4 units)
Developmental biology of animals at the tissue, cellular, and molecular levels. Basic processes of embryogenesis in a variety of invertebrate and vertebrate organisms. Cellular and molecular mechanisms that underlie cell fate determination and cell differentiation. More advanced topics such as pattern formation and sex determination are discussed. Open to upperdivision students only.
Prerequisites: upperdivision standing; BICD 100; BIBC 100 or BIBC 102; BICD 110 strongly recommended, BIMM 100 strongly recommended. 
BGGN 222. Graduate Cell Biology (6 units)
A coverage of modern cell biology for first year graduate students. There is an uptodate discussion of topics such as: structure and function of membranes; ion pumps, ion channels, transmembrane signaling; receptor mediated endocytosis; protein targeting; the role of RER and Golgi apparatus; the biosynthesis of intracellular organelles in animal and plant cells; the cytoskeleton, motility, molecular motors, cellcell interactions, mitosis; and the control of cell division. Also included are extensive coverage of cell signaling mechanisms and discussions on molecular approaches to cell biology.
Prerequisites: BGGN 220 and 221. OPEN ONLY TO STUDENTS ENROLLED IN A GRADUATE DEGREE PROGRAM. (Letter grades only.) (W) 
CHEM 221 / BGGN 230. Signal Transduction (4 units)
The aim of this course is to develop an appreciation for a variety of topics in signal transduction. We will discuss several historical developments while the focus will be on current issues. Both experimental approaches and results will be included in our discussions. Topics may vary from year to year.
Prerequisites: biochemistry and molecular biology. (May not be offered every year.)
Elective CS1: Algorithms

CSE 101. Design and Analysis of Algorithms (4 units)
Design and analysis of efficient algorithms with emphasis of nonnumerical algorithms such as sorting, searching, pattern matching, and graph and network algorithms. Measuring complexity of algorithms, time and storage. NPcomplete problems. Credit not offered for both Math 188 and CSE 101. Equivalent to Math 188.
Prerequisites: CSE 12, CSE 21 or Math 15B, or Math 100A, or Math 103A and CSE 100, or Math 176. 
CSE 200. Computability and Complexity (4 units)
Graduate
CSE 200. Computability and Complexity (4)
Computability review, including halting problem, decidable sets, r.e. sets, manyone reductions; TIME(t(n)), SPACE(s(n)) and general relations between these classes; L, P, PSPACE, NP; NP—completeness; hierarchy theorems; RP, BPP.
Prerequisites: CSE 105 or equivalent. 
CSE 202. Algorithm Design and Analysis (4 units)
The basic techniques for the design and analysis of algorithms. Divideandconquer, dynamic programming, data structures, graph search, algebraic problems, randomized algorithms, lower bounds, probabilistic analysis, parallel algorithms.
Prerequisites: CSE 101 or equivalent. 
CSE 280A. Algorithms in Computational Biology (4 units)
(Formerly CSE 206B.) The course focuses on algorithmic aspects of modern bioinformatics and covers the following topics: computational gene hunting, sequencing, DNA arrays, sequence comparison, pattern discovery in DNA, genome rearrangements, molecular evolution, computational proteomics, and others.
Prerequisites: CSE 202 preferred or consent of instructor. 
MATH 261A. Probabilistic Combinatorics and Algorithms (4 units)
Introduction to the probabilistic method. Combinatorial applications of the linearity of expectation, second moment method, Markov, Chebyschev, and Azuma inequalities, and the local limit lemma. Introduction to the theory of random graphs.
Prerequisites: graduate standing or consent of instructor.
Elective CS2: Machine Learning and Data Mining

CSE 250A. Principles of Artificial Intelligence: Probabilistic Reasoning and Learning (4 units)
Methods based on probability theory for reasoning and learning under uncertainty. Content may include directed and undirected probabilistic graphical models, exact and approximate inference, latent variables, expectationmaximization, hidden Markov models, Markov decision processes, applications to vision, robotics, speech, and/or text. Recommended preparation: CSE 103 or similar course.
Prerequisites: graduate standing in CSE or consent of instructor. 
CSE 250B. Principles of Artificial Intelligence: Learning Algorithms (4 units)
Algorithms for supervised and unsupervised learning from data. Content may include maximum likelihood; loglinear models, including logistic regression and conditional random fields; nearest neighbor methods; kernel methods; decision trees; ensemble methods; optimization algorithms; topic models; neural networks; and backpropagation. Recommended preparation: CSE 103 or similar course.
Prerequisites: graduate standing or consent of instructor.
Elective CS3: Mathematics and Statistics

MATH 274. Numerical Methods for Physical Modeling (4 units)
(Conjoined with Math 174.) Floating point arithmetic, direct and iterative solution of linear equations, iterative solution of nonlinear equations, optimization, approximation theory, interpolation, quadrature, numerical methods for initial and boundary value problems in ordinary differential equations. Students may not receive credit for both Math 174 and PHYS 105, AMES 153 or 154. (Students may not receive credit for Math 174 if Math 170A, B, or C has already been taken.) Graduate students will complete an additional assignment/exam.
Prerequisites: Math 20D or 21D, and either Math 20F or Math 31AH, or consent of instructor. 
MATH 280A. Probability Theory (4 units)
Probability measures; Borel fields; conditional probabilities, sums of independent random variables; limit theorems; zeroone laws; stochastic processes. (This is a description of the full year Math 280ABC.)
Prerequisites: advanced calculus and consent of instructor. (F) 
MATH 281A. Mathematical Statistics (4 units)
Statistical models, sufficiency, efficiency, optimal estimation, least squares and maximum likelihood, large sample theory.
Prerequisites: advanced calculus and basic probability theory or consent of instructor. 
MATH 281B. Mathematical Statistics (4 units)
Hypothesis testing and confidence intervals, onesample and twosample problems. Bayes theory, statistical decision theory, linear models and regression.
Prerequisites: advanced calculus and basic probability theory or consent of instructor. 
PHYS 210A. Equilibrium Statistical Mechanics (5 units)
Approach to equilibrium: BBGKY hierarchy; Boltzmann equation; Htheorem. Ensemble theory; thermodynamic potentials. Quantum statistics; Bose condensation. Interacting systems: Cluster expansion; phase transition via meanfield theory; the Ginzburg criterion.
Prerequisites: Physics 200A–B. Corequisites: Physics 212C. (S) 
PHYS 210B. Nonequilibrium Statistical Mechanics (4 units)
Transport phenomena; kinetic theory and the ChapmanEnskog method; hydrodynamic theory; nonlinear effects and the mode coupling method. Stochastic processes; Langevin and FokkerPlanck equation; fluctuationdissipation relation; multiplicative processes; dynamic field theory; MartinSiggiaRose formalism; dynamical scaling theory.
Prerequisites: Physics 210A. (F)
Elective SB1: Biological Systems

BENG 211. Systems Biology and Bioengineering I: Biological Components (4 units)
Components of biological systems, their biochemical properties and function. The technology used for obtaining component lists. Relationship within and integration of component lists. Structured vocabularies and component ontologies. Algorithms for comparative approaches in deciphering and mining component lists.
Prerequisites: BENG 230A or BIMM 100, or consent of instructor. (F) 
BENG 212. Systems Biology and Bioengineering II: Network Reconstruction (4 units)
This course will cover the process of reconstructing complex biological reaction networks. Reconstruction of metabolic networks, regulatory networks and signaling networks. Bottomup and topdown approaches. The use of collections of historical data. The principles underlying highthroughput experimental technologies and examples given on how this data is used for network reconstruction, consistency checking, and validation.
Prerequisites: BENG 211 or consent of instructor. (W) 
BENG 227. Transport Phenomena in Living Systems (4 units)
This course describes the movement of heat and chemical mass in biological systems. Diffusion, convection and biochemical reactions in a variety of biological and engineering examples are analyzed and modeled. Students that have taken BENG 222 cannot take BENG 227 for credit. Prerequisites: BENG 221, graduate standing, or consent of instructor. (S)
Elective SB2: Kinetic Modeling

BENG 125. Modeling and Computation in Bioengineering (4 units)
Computational modeling of molecular bioengineering phenomena: excitable cells, regulatory networks, and transport. Application of ordinary, stochastic, and partial differential equations. Introduction to data analysis techniques: power spectra, wavelets, and nonlinear time series analysis.
Prerequisites: BENG 122A or BENG 123 or consent of department. (S) 
BNFO 284. Nonlinear Dynamics in Quantitative Biology (4 units)
Qualitative, analytical and computational mathematical modeling techniques applied to regulatory networks and signaling networks. Stability, bifurcations, oscillations, multistability, hysteresis, multiple timescales, and chaos. Introduction to experimental data analysis and control techniques. Applications to synthetic biology, cellular population dynamics, ad canonical signaling networks (inflammation, tumor suppression, metabolism). Letter grades only.
Prerequisites: bioinformatics and systems biology graduate students only. 
PHYS 276. Quantitative Molecular Biology (4 units)
A quantitative approach to gene regulation, including transcriptional and posttranscriptional control of gene expression, as well as feedback and stochastic effects in genetic circuits. These topics will be integrated into the control of bacterial growth and metabolism. Recommended preparation: an introductory course in biology is helpful but not necessary. (W)

CHEM 220. Regulatory Circuits in Cells (4 units)
Modulation cellular activity and influencing viral fate involve regulatory circuits. Emergent properties include dose response, crossregulation, dynamic, and stochastic behaviors. This course reviews underlying mechanisms and involves mathematical modeling using personal computer tools. Recommended: some background in biochemistry and/or cellular biology. Mathematical competence at the level of lowerdivision college courses.
Elective BMI1: Biomedical Informatics

MED 263. Bioinformatics Applications to Human Disease (4 units)
Students learn background knowledge and practical skills for investigating the biological basis for human disease. Using bioinformatics applications, they: (1) query biological and genetic sequence databases relevant to human health, (2) manipulate sequence data for alignment, recombination, selection, and phylogenetic analysis, (3) normalize microarray data and identify differentially expressed genes and biomarkers between patient groups, (4) annotate protein data and visualize protein structure, and (5) search the human genome and annotate genes relevant to human diseases. (W)

MED 265. Introduction to Clinical Environments (2 units)
Students are introduced to the basics of healthcare systems through direct observation and classroom discussion. Students are introduced to medical language, disease processes, and health care practices to provide context prior to direct patient observation at primary, specialty, emergency, and inpatient sites in conjunction with clinical faculty affiliated with the training program. Students examine how clinicians use historytaking, physical examination and diagnostic testing to establish diagnoses and prognoses. Medical decisionmaking is introduced in the context of available informatics tools and clinical documentation and communication processes. Postobservation classroom discussions encourage students to think critically of the processes they observed and formulate hypotheses about how informatics solutions can modify the processes. Students who already have a clinical background can substitute this course. (W)

MED 267. Modeling Clinical Data and Knowledge for Computation (2 units)
This course describes existing methods for representing and communicating biomedical knowledge. The course describes existing health care standards and modeling principles required for implementing data standards, including biomedical ontologies, standardized terminologies, and knowledge resources. (F, offered alternate years.)

MED 268. Statistics Concepts for Biomedical Research (4 units)
Introduction of statistics methods including descriptive statistics, ttests, ANOVA, linear and logistic regression, survival analysis, power and sample size, nonparametric methods, and factorial experiment design. Students perform statistical analysis using R statistics software and critique statistical resuls in published research. (F)
Prerequisites: Medical or Graduate Student 
MED 269. Clinical Decision Support Systems at the Point of Care (4 units)
Students learn about modeling knowledge to facilitate improved decisionmaking. The course includes review and discussion of case studies of specific healthrelated decisionsupport systems. Through discussions, assignments, and group projects, students learn the analytic techniques behind decision support systems as well as topics within decisionmaking under uncertainty, decision analysis, and evaluation of decision support systems. (W)

MED 273. Communicating Biomedical Informatics (4 units)
Students learn writing techniques for communicating scientific and engineering knowledge to audiences ranging from specialist to general communities. Starting with a review of grammar and sentence structure, the course will lead into different forms of science and engineering writing, including popular pieces, blogs, specifications, reviews, and research papers. Additionally, techniques to improve scientific presentation skills in oral form will be offered. (W, offered alternate years.)

MED 276. Grant Proposal Writing Practicum (2 units)
The focus of this course will be on grant writing and developing persuasive arguments. Previously submitted funded and nonfunded grants will be used to illustrate revision and response to reviewers, as well as to provide source materials to perform mock study section reviews. This course will help students write their first grant proposal and understand the process of proposal scoring and reviewing. (S, offered alternate years.)

MED 277. Introduction to Biomedical Natural Language Processing (4 units)
Biomedical Natural Language Processing (BioNLP) is an essential tool in both biomedical research and clinical applications. Students taking this course will learn how to process free text data and their integration with other types of biomedical data with BioNLP.
Note: This is a proposed new course currently undergoing the approval process. It is expected to be offered in 201516 if it is approved in time.