Dynamical Systems, Stochastic Processes, and Biological Circuits
We are interested in all aspects of gene regulation, and have used model systems including cells of the immune system, embryonic stem cells, haematopoietic stem cells and cells of the mouse embryo.
Our laboratory aims to obtain a quantitative and predictive understanding of how complex biological systems operate and function. We focus on the two complementary directions: systems biology analysis to deconstruct natural systems and synthetic biology to build artificial systems analogous to natural systems.
Our research focuses on molecular engineering for cellular imaging and reprogramming, and image-based bioinformatics, with applications in stem cell differentiation and cancer treatment.
We are interested in fundamental questions in biology, and we bring tools and ways of thinking from physical sciences and engineering. Researchers in our lab are proficient in both experiment and theory.
We have a wide scope of projects ranging from developing novel algorithms for studying RNA processing in diseases, development and personalized medicine, and for analyzing single-cell RNA-seq data.