Epigenome-wide inheritance of cytosine methylation variants in a recombinant inbred population.

TitleEpigenome-wide inheritance of cytosine methylation variants in a recombinant inbred population.
Publication TypeJournal Article
Year of Publication2013
AuthorsSchmitz RJ, He Y, Valdés-López O, Khan SM, Joshi T, Urich MA, Nery JR, Diers B, Xu D, Stacey G, Ecker JR
JournalGenome Res
Volume23
Issue10
Pagination1663-74
Date Published2013 Oct
ISSN1549-5469
Abstract

Cytosine DNA methylation is one avenue for passing information through cell divisions. Here, we present epigenomic analyses of soybean recombinant inbred lines (RILs) and their parents. Identification of differentially methylated regions (DMRs) revealed that DMRs mostly cosegregated with the genotype from which they were derived, but examples of the uncoupling of genotype and epigenotype were identified. Linkage mapping of methylation states assessed from whole-genome bisulfite sequencing of 83 RILs uncovered widespread evidence for local methylQTL. This epigenomics approach provides a comprehensive study of the patterns and heritability of methylation variants in a complex genetic population over multiple generations, paving the way for understanding how methylation variants contribute to phenotypic variation.

DOI10.1101/gr.152538.112
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/23739894?dopt=Abstract
PMCPMC3787263
Alternate JournalGenome Res.
PubMed ID23739894