Single Cell Transcriptomics of the Cocaine Use Disorder in the Context of HIV

As part of the NIH NIDA SCORCH consortium, we will dissect the dysregulated molecular circuitry in the brains of individuals with cocaine use disorder and/or HIV infection. This project will focus on understanding how neurovasculature and neuroimmune cells contribute to cocaine use disorder and HIV-associated neurocognitive disorders. We will be generating snRNA-seq and snATAC-seq profiles from more than 300 patient samples across 3 different brain regions.