The 3D Tumor Genome

To identify molecular mechanisms that contribute to tumor development and maintenance, we develop hypotheses driven computational tools for the integrative analysis of different layers of genetic and epigenetic information. As we recognized that our epigenetic mapping studies can identify effective drug targets, we are now profiling 3D tumor genomes to uncover molecular mechanisms that may cause disturbed enhancer-gene interactions leading to deregulation of gene expression and biochemical pathways.