Adder and a coarse-grained approach to cell size homeostasis in bacteria.

TitleAdder and a coarse-grained approach to cell size homeostasis in bacteria.
Publication TypeJournal Article
Year of Publication2016
AuthorsSauls JT, Li D, Jun S
JournalCurr Opin Cell Biol
Volume38
Pagination38-44
Date Published2016 Feb
ISSN1879-0410
Abstract

Cell size control and homeostasis is a long-standing subject in biology. Recent experimental work provides extensive evidence for a simple, quantitative size homeostasis principle coined adder (as opposed to sizer or timer). The adder principle provides unexpected insights into how bacteria maintain their size without employing a feedback mechanism. We review the genesis of adder and recent cell size homeostasis study on evolutionarily divergent bacterial organisms and beyond. We propose new coarse-grained approaches to understand the underlying mechanisms of cell size control at the whole cell level.

DOI10.1016/j.ceb.2016.02.004
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/26901290?dopt=Abstract
Alternate JournalCurr. Opin. Cell Biol.
PubMed ID26901290
Track(s): 
Bioinformatics and Systems Biology