Adder and a coarse-grained approach to cell size homeostasis in bacteria.
|Title||Adder and a coarse-grained approach to cell size homeostasis in bacteria.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Sauls JT, Li D, Jun S|
|Journal||Curr Opin Cell Biol|
|Date Published||2016 Feb|
Cell size control and homeostasis is a long-standing subject in biology. Recent experimental work provides extensive evidence for a simple, quantitative size homeostasis principle coined adder (as opposed to sizer or timer). The adder principle provides unexpected insights into how bacteria maintain their size without employing a feedback mechanism. We review the genesis of adder and recent cell size homeostasis study on evolutionarily divergent bacterial organisms and beyond. We propose new coarse-grained approaches to understand the underlying mechanisms of cell size control at the whole cell level.
|Alternate Journal||Curr. Opin. Cell Biol.|